Page 37 - 2021

M.Phil
(Science- Chemistry)
SYNTHESIS AND CHARACTERIZATION OF HETEROCYCLIC
DERIVATIVES AND ITS APPLICATION

M.Phil. Scholar : Vishal Rana
Research Supervisor : Dr. Keyur D. Bhatt

Regi. No.: 20065151001
Abstract :
From the past few decades, chalcone has become a matter of focus due to its wide range
of biological activities including anti-inflammation, anticancer, antitubercular, etc. Due to
its inherent chemical reactivity, chalcone has become an easily accessible building block
to construct various naturally and biologically active compounds. In modern times, the
title compound is made possible to prepare through Claisen-Schmidt reaction or Aldol
reaction. However, under a conventional condition, it is carried out with a considerable
number of variables (time, temperature, reagents, instrument parameters, etc.). In the
present research work, we report a novel series of chalcone-based heterocyclic moieties
along with an eco-friendly condensation reaction method permitting a ‘green approach’ to
the present work. The reaction progress was followed by thin-layer chromatography
(TLC), and Rf values were recorded. I.R. Spectral data for all the synthesized derivatives
were reported. The objective of the present research work is also the utility of green
methodologies for the synthesis of the desired compound. In comparison with traditional
methods, these methods were more convenient and provided higher yield (75-80%),
shows maximum efficiency, held without generation of pollution along with therapeutic
application at the same time. This approach has a shorter reaction time, is safer for
analysts, is low cost, and is simple to run.

Key words: Chalcone, Pyrazoline, Pyrimidine, Ultrasound.

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