Page 34 - 2021

Ph.D.
(Science)
FUNCTIONALIZED SUPRAMOLECULAR ASSEMBLIES:
SYNTHESIS, CHARACTERIZATION AND APPLICATIONS

Ph.D. Scholar : Desai Ajay Lalbhai
Research Supervisor : Dr. Keyur D. Bhatt

Regi. No.: 17276461001
Abstract :
Present work comprises six chapters, which begins with an extensive literature survey on
supramolecular receptors especially third generation receptors calixarene emphasizing
calix[4]pyrrole family. Further mechanism and various possible functionalization of
calix[4]pyrrole has been successfully embossed. Further attempts on utilization
(applications) of this functionalized calix[4]pyrrole have also been discussed.

This literature survey is followed by the conventional and microwave assisted synthesis
methods and characterization of calix[4]pyrrole moieties (ABCP & ABuCP) and their
corresponding derivatives (ABCPTAA, ABCPTAQ, and ABuCPTAA).

The further chapter emphasizes the generation of CPOH based PdNPs. Furthermore, they
were utilized as efficient nanocatalysts for various C-C coupling reactions and the results
confirm they can easily be recovered, reused with the same efficiency without
considerable loss in their catalytic activity.

In addition, recognition of amino acid and interaction of a novel calix[4]pyrrole system
bearing carboxylic acid functionality (ABCP) has been investigated towards amino acids
in methanol in the following chapter. ABCP showed remarkable color change with
Tryptophan (Trp) in comparison to other amino acids. The ABCP-Tryptophan complex
showed 1:1 stoichiometry. Additionally, the same one is very well supported by density
functional theory calculations. Also to explore the applications of sensors for guest
analytes (antibiotics and metals), we have derivatised above calix[4]pyrrole (ABCP) with
amino-anthraquinone and amino-quinoline i.e. ABCPTAA and ABCPTAQ which resulted in
generation of high fluorescence capability sensor.

Besides, the interaction of a novel calix[4]pyrrole system bearing carboxylic acid
functionality (ABuCP) towards various nitroaromatics compounds (NACs) was
investigated. Additionally, the density functional theory calculations confirm the possible
mechanism for the binding of 1,3-DNB with ABuCP theoretically. We have also developed
its derivative which acts as a new fluorescent sensor that can selectively recognize a
guest analyte (metal ions). In this view aminoanthraquinone derivative of calix[4]pyrrole
i.e. ABuCPTAA is synthesized which also results in the generation of high fluorescence
capability sensor. Also, the complexation has been substantiated by Job’s plot which
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