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fluorescence quenching effect, validating the potential of CTCHN2EPh as a selective
chemosensor for ytterbium (III) detection. The narrative deepens with Density Functional
Theory (DFT) studies, unraveling a photoinduced electron transfer pathway and shedding
light on the ligand-to-metal charge transfer mechanism. Binding constants, Job's plot
analysis, and Limit of Detection (LOD) calculations add the finishing touches, establishing
CTCHN2EPh's credentials as an efficient chemosensor.

Chapter 4 unveils the development of a propyl-phthalimide functionalized
Cyclotricatechylene chemosensor designed for the effective detection of sulfosulfuron, a
prominent pesticide. The narrative weaves through the optimization of the ligand, docking
studies indicating high affinity, and experimental studies showcasing significant
fluorescence enhancement upon interaction with sulfosulfuron. Density Functional
Theory (DFT) studies provide a deeper understanding of charge transfer mechanisms,
adding complexity to the chemosensor's story. Binding constants, Job's plot analysis, and
Limit of Detection (LOD) calculations bring a satisfying conclusion, positioning the
CTCHN3PPh derivative as a promising candidate for pesticide detection.

Chapter 5 introduces a fluorescent chemosensor based on a tri-N-(benzo[d]thiazol-2-
yl)acetamide functionalized cyclotriguaiacylene derivative, designed for the highly
selective detection of Cu(II) metal ions. The plot thickens with the stepwise synthesis of
the CTGTNBTA derivative, characterized through various spectroscopic techniques. UV-
Visible spectroscopy steals the spotlight, revealing a notable shift in absorption peaks
upon interaction with Cu(II) ions. Fluorescence spectroscopy adds drama, showcasing
significant quenching and establishing the CTGTNBTA derivative as a selective
chemosensor. Density Functional Theory (DFT) studies dive into the binding mechanism,
while binding constant determination and Limit of Detection (LOD) calculations provide a
satisfying conclusion, setting the stage for the CTGTNBTA derivative's potential in metal
ion detection.

Chapter 6 unfolds the biological saga of Cyclotriveratrylene derivatives, specifically
CTCHN2EPh, CTCHN3PPh, and CTGTNBTA. The MTT assay takes center stage, revealing
the anticancer potential of these derivatives against the MCF-7 breast cancer cell line.
Notably, our exploration delves further into the intricacies of anti-cancer properties, as we
conduct docking and dynamics studies to unravel the molecular intricacies underlying
CTGTNBTA's anticancer activity. The chapter then pivots to the evaluation of CTGTNBTA's
anti-tuberculosis activity, showcasing its varying effectiveness at different concentrations
against Mycobacterium Tuberculosis. The biological studies add a compelling layer to the
thesis, suggesting the potential of these derivatives in future cancer treatments and as
candidates for tuberculosis drug development

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