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Ph.D.
(Science)
SYNTHESIS, CHARACTERIZATION AND APPLICATIONS OF SOME
FUNCTIONALIZED MACROMOLECULAR RECEPTORS

Ph.D. Scholar : Patel Nihalkumar Pravinbhai
Research Supervisor : Dr. Krunal M. Modi & Dr. Keyur D. Bhatt

Regi. No.: 20276461003
Abstract :
In this research endeavor, we embark on an exploration of the captivating realm of
supramolecular chemistry, immersing ourselves in the concept of chemistry that extends
beyond the confines of the molecule. Professor J. M. Lehn's eloquent definition of
supramolecular chemistry as the intricate association of chemical species through
intermolecular forces serves as our guiding principle, laying the foundation for
comprehending the multifaceted interactions inherent in this field, encompassing
hydrogen bonding and metal coordination. Within the pages of this study, we navigate the
evolutionary path of supramolecular components, shining a spotlight on the pivotal role
played by calixarenes, particularly Cyclotriveratrylene (CTV), in the domain of receptor
chemistry. As we delve deeper, tantalizing glimpses emerge of the potential applications
of CTV-functionalized macrocyclic receptors, alluding to their catalytic prowess, adept
sensing of hazardous metal ions, and prospective contributions to critical biological
activities such as anticancer and anti-TB research. This research, mirroring the trajectory
of Chapter 1, unveils the intricate tapestry of supramolecular chemistry, emphasizing the
significance of these molecular interactions in diverse domains.

Chapter 2 takes a deep dive into the synthesis and characterization of Cyclotriveratrylene
(CTV) derivatives. The narrative unfolds with the synthesis of the CTV parent compound,
followed by the demethylation process to obtain Cyclotricatechylene (CTC) and
cyclotriguaiacylene (CTG). The plot thickens as CTV derivatives are then skillfully
functionalized with different fluorophores, producing compounds like CTCHN2EPh,
CTCHN3PPh, and CTGTNBTA. Characterization techniques, including FTIR, ESI-MS, and
1H NMR spectroscopy, come into play to unveil the structures and properties of these
synthesized derivatives. This chapter lays a solid foundation for understanding CTV
derivatives and hints at their potential applications in fluorescence-based sensing and
molecular recognition.

Chapter 3 emerges as a computational and experimental thriller, focusing on the
synthesis and sensing of ytterbium (III) using a hexa-ethyl phthalimide-functionalized
Cyclotricatechylene. The drama unfolds with computational docking studies revealing the
optimized ligand's high affinity for ytterbium (III). Experimental studies confirm the

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