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Ph.D.
(Pharmacy)
CORRELATION STUDY OF VITAMIN D STATUS WITH
VARIOUS DISEASE CONDITIONS

Ph.D. Scholar : Chaudhary Pruthviraj Karashanbhai
Research Supervisor : Dr. Satish A. Patel

Regi. No.: 18276011001
Abstract :
Background: The aim and objectives of this study was to evaluate the Vitamin D status
and its association with various disease conditions. Understanding this correlation is
essential to gain insights into the prevalence of Vitamin D deficiency in relation to
Diabetes, Anaemia, Cholesterol, Thyroid, Testosterone and PSA among the people of this
region.

Methods: A retrospective analysis was conducted using data from subjects (>18 years)
who underwent laboratory investigation includes the estimation of Vitamin D3 and with it
estimation of HbA1c, Iron, Haemoglobin, Lipid parameters, Thyroid parameters,
Testosterone, PSA at various study sites across north Gujarat, India. The primary
variables studied were the proportions of subjects with different Vitamin D (25(OH)D)
total levels, classified as deficiency (<30 ng/ml) or Sufficiency (30-100 ng/ml).
Results: The analysis included data from 1109 subjects with a mean age of 46.97
(±13.39) years. Among them, 941 (84.9%) had Vitamin D levels below 30 ng/ml, with a
slightly higher prevalence in males (85.78%) compared to females (83.81%). The age
group with the highest incidence of vitamin D levels below 30 ng/ml was 21 – 40 years
(87.17%), followed by > 60 years (86.34%), and 41 – 60 years (82.57%). In Diabetes group,
666 (60.05%) subjects were Diabetic, while 443 (39.95%) were Non-Diabetic. Regarding
Iron deficient anaemia group, [290 (26.1%) {M-140(23.97%)} {F-150(28.57%)}] subjects
were Iron deficient anaemic, while [819 (73.9%) {M-444(76.03%)} {F-375(71.43%)}] had
normal Iron levels. From Anaemic (Hb) subjects group, [255 (22.99%) {M-99(16.95%)} {F-
156(29.71%)}] were Anaemic (low Hb), while [854 (77.01%) {M-485(83.05%)} {F-
369(70.29%)}] were having normal value of Haemoglobin. Further, in Lipid disorder
subject, 623 (56.18%) had abnormal levels, while 486(43.82%) had normal levels.
Regarding Thyroid profiles, 1000 (90.2%) subjects had levels within the normal range,
while 109 (9.8%) had abnormallity. In Testosterone group, 620 (55.9%) subjects had levels
within the normal range of Testosterone, while 489 (44.1%) had abnormal Testosterone.
At last, Regarding PSA group from 186 subjects; 184 (98.92%) subjects had levels within
the normal range, while 02 (1.08%) had abnormal PSA.
Conclusions: Study reveals high prevalence of Vitamin D deficiency among the population

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